Targeting von Willebrand Factor–Mediated Inflammation
نویسندگان
چکیده
منابع مشابه
Targeting von Willebrand Factor-Mediated Inflammation.
In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Aymé et al provide new insights into the role played by von Willebrand factor (VWF) in modulating in vivo inflammatory responses. In particular, a single-domain antibody against the VWF A1 domain is shown to markedly attenuate leukocyte recruitment and vascular permeability in 2 distinct murine models of inflammation. Collecti...
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Von Willebrand factor (VWF) is synthesized in endothelial cells, stored in the form of high molecular weight multimers and released after stimulation. After release, the multimers are cleaved by ADAMTS13 (von-Willebrand-factor-cleaving protease). We studied healthy volunteers in a double-blind, placebo controlled inflammation model. Ten male volunteers received 2 ng/kg endotoxin intravenously, ...
متن کاملDefining von Willebrand disease.
for repeat testing. The authors’ conclusion that it should be considered for screening patients requires further consideration and study but conceivably, this assay should improve the future of VWD diagnosis. Conflict-of-interest disclosure: P.D.J. has received research funding from Bayer, CSL Behring, and Octapharma; and honoraria for educational talks from Baxalta, CSL Behring, and Octapharma. n
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2017
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.117.309817